INTERACTIONS OF NUCLEIC-ACIDS WITH DISTAMYCINS - BINDING OF DST-3 TO D(CGTTTAAACG)2 AND D(CGTACGTACG)2

被引：11

作者：

CAPOBIANCO, ML

COLONNA, FP

FORNI, A

GARBESI, A

IOTTI, S

MORETTI, I

SAMORI, B

TONDELLI, L

机构：

[1] UNIV BOLOGNA,DIPARTMENTO CHIM ORGAN,VIALE RISORGIMENTO 4,I-40136 BOLOGNA,ITALY

[2] CNR,ICOCEA,I-40064 OZZANO EMILIA,ITALY

[3] UNIV MODENA,DIPARTMENTO CHIM,I-41100 MODENA,ITALY

来源：

NUCLEIC ACIDS RESEARCH | 1991年 / 19卷 / 07期

关键词：

D O I：

10.1093/nar/19.7.1695

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The binding between Distamycin 3 and the palindromic duplexes d(CGTTTAAACG)2 and d(CGTACGTACG)2 was investigated by two indipendent techniques: UVVis absorption in the Job's plot approach and Induced Circular Dichroism. Both decamers bind two molecules of peptide per duplex, with close overall affinities. This result indicates that a row of six A:T base pairs can accommodate two molecules of drug and that the minimal binding site of Distamycin 3 can consist of just two A:T base pairs.

引用

页码：1695 / 1698

页数：4

共 29 条

[1]

AMES BN, 1960, J BIOL CHEM, V235, P769

[2] SOME STRUCTURAL REQUIREMENTS FOR ANTIBIOTIC ACTION OF DISTAMYCINS .2. STRUCTURAL MODIFICATION OF SIDE CHAINS IN DISTAMYCIN A MOLECULE [J].