ALTERED GLUCOSE-METABOLISM IN ADRIAMYCIN-INDUCED HEART-FAILURE

被引：13

作者：

CHATHAM, JC ^{[1
]}

HUTCHINS, GM ^{[1
]}

GLICKSON, JD ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT PATHOL,BALTIMORE,MD 21205

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1138卷 / 01期

关键词：

NMR; C-13-; GLYCOLYSIS; TCA CYCLE; DOXORUBICIN; (HEART FAILURE);

D O I：

10.1016/0925-4439(92)90143-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Spontaneously hypertensive rats received 1 mg/kg of Adriamycin intravenously once a week for up to 12 weeks; their hearts were excised and perfused with buffer containing 5 mM [1-C-13]glucose. Histological evidence of Adriamycin cardiotoxicity was evident after 8 and 12 weeks of treatment and was accompanied by a significant decrease in cardiac function. There were only minor changes in the P-31-NMR spectra in hearts following treatment; however, C-13-NMR spectra revealed decreased incorporation of label into the lactate, alanine and glutamate pools in hearts with severe tissue damage compared to hearts from untreated animals.

引用

页码：1 / 5

页数：5

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