IMMUNOCYTOCHEMICAL AND ULTRASTRUCTURAL STUDIES OF NEURONAL AND OLIGODENDROGLIAL CYTOPLASMIC INCLUSIONS IN MULTIPLE SYSTEM ATROPHY .2. OLIGODENDROGLIAL CYTOPLASMIC INCLUSIONS

被引：83

作者：

MURAYAMA, S

ARIMA, K

NAKAZATO, Y

SATOH, J

ODA, M

INOSE, T

机构：

[1] UNIV N CAROLINA,SCH MED,DEPT PATHOL,DIV NEUROPATHOL,CHAPEL HILL,NC 27514

[2] NATL CTR HOSP MENTAL NERVOUS & MUSCULAR DISORDERS,DEPT PSYCHIAT,KODAIKA,JAPAN

[3] GUNMA UNIV,SCH MED,DEPT PATHOL,MAEBASHI,GUNMA 371,JAPAN

[4] TOKYO METROPOLITAN INST NEUROSCI,DEPT CLIN PATHOL,FUCHU,TOKYO 183,JAPAN

[5] TOKYO METROPOLITAN NEUROL HOSP,DEPT PATHOL & LAB,FUCHU,JAPAN

来源：

ACTA NEUROPATHOLOGICA | 1992年 / 84卷 / 01期

关键词：

MULTIPLE SYSTEM ATROPHY; OLIGODENDROGLIAL CYTOPLASMIC INCLUSIONS; ALPHA-B-CRYSTALLIN; UBIQUITIN; IMMUNOCYTOCHEMISTRY;

D O I：

10.1007/BF00427212

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Oligodendroglial cytoplasmic inclusions (OCI) in multiple system atrophy were investigated immunocytochemically and ultrastructurally. Among the 17 cases examined, 16 had OCIs. Almost all OCIs were positive for both alpha-B-crystallin and ubiquitin. The antibodies against tubulin, paired helical filament and tau stained OCIs to various extents. Ultrastructurally OCIs consisted of meshworks of granule-associated filaments about 25 nm in diameter that sometimes formed flame-shaped tangle-like structures. Immunoelectron microscopy showed that an epitope of alpha-B-crystallin was located on the granule-associated filaments composing OCIs. Our studies further support a cooperative role of alpha-B-crystallin, ubiquitin and cytoskeletal protein in the formation of some types of intracytoplasmic inclusions.

引用

页码：32 / 38

页数：7

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