A COMPARATIVE-STUDY OF THE IN-VITRO AND IN-VIVO ANTIVIRAL ACTIVITIES OF ACYCLOVIR AND PENCICLOVIR

被引：25

作者：

ERTL, P ^{[1
]}

SNOWDEN, W ^{[1
]}

LOWE, D ^{[1
]}

MILLER, W ^{[1
]}

COLLINS, P ^{[1
]}

LITTLER, E ^{[1
]}

机构：

[1] BURROUGHS WELLCOME CO, RES TRIANGLE PK, NC 27709 USA

来源：

ANTIVIRAL CHEMISTRY & CHEMOTHERAPY | 1995年 / 6卷 / 02期

关键词：

ACYCLOVIR; ANTIVIRAL; PENCICLOVIR;

D O I：

10.1177/095632029500600203

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The antiviral properties of the compounds acyclovir (ACV) and penciclovir (PCV) have been compared in a number of in vitro and in vivo assays. In vitro, both compounds had good activity against herpes simplex virus type 1 (HSV-1) acid varicella-zoster virus (VZV), although ACV showed statistically significant superiority, In addition, ACV had greater activity against herpes simplex virus type 2 (HSV-2), human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV). We examined the effect of time of addition and removal of ACV and PCV under a variety of conditions and found similar results with the two compounds under most conditions, However, at a high multiplicity of infection, when all of the cells would be expected to be synchronously expressing large amounts of the viral thymidine kinase, short exposures to PCV appeared to be superior to similar exposures to ACV, In the HSV-1 zosteriform mouse model there was no significant difference between the activities of ACV and PCV, or its prodrug famciclovir (FCV), in once- or twice-daily treatment. The possible significance of these results and those previously reported on the activity of the compounds in humans is discussed.

引用

页码：89 / 97

页数：9

共 36 条

[1] CYTOPLASMIC RNA FROM NORMAL AND MALIGNANT HUMAN-CELLS SHOWS HOMOLOGY TO THE DNAS OF EPSTEIN-BARR VIRUS AND HUMAN ADENOVIRUSES [J].