A CLINICOPATHOLOGICAL STUDY OF 24 CHILDREN WITH HEMOLYTIC UREMIC SYNDROME - A REPORT OF THE SOUTHWEST PEDIATRIC NEPHROLOGY STUDY-GROUP

被引：48

作者：

ARGYLE, JC ^{[1
]}

HOGG, RJ ^{[1
]}

PYSHER, TJ ^{[1
]}

SILVA, FG ^{[1
]}

SIEGLER, RL ^{[1
]}

机构：

[1] BAYLOR UNIV,MED CTR,DEPT PEDIAT,3500 GASTON AVE,DALLAS,TX 75246

来源：

PEDIATRIC NEPHROLOGY | 1990年 / 4卷 / 01期

关键词：

Hemolytic uremic syndrome; Renal failure; Thrombotic microangiopathies;

D O I：

10.1007/BF00858440

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

This study reports the pattern of renal injury in 24 North American children with hemolytic uremic syndrome (HUS), and the extent of extrarenal involvement in 9 of these children examined at autopsy. Fifteen of the 24 children were studied during the first 16 days of hospital-ization; their renal specimens demonstrated glomerular thrombotic microangiopathy (TMA) in 8 children, cortical necrosis in 1, and varying degrees of glomerular TMA and cortical necrosis in 6 children. Nine of the children were studied after 16 or more days of hospitalization; these patients had prominent renal arterial lesions. Of 9 children examined at autopsy, extrarenal microthrombi were identified in 8. In 4 children who died during the acute phase of the disease, hemorrhagic colonic necrosis (3 children) and pancreatic islet cell necrosis (2 children) were the principal extrarenal lesions encountered. Rare microthrombi were present in the brains of the 3 children who manifested seizures. © 1990 IPNA.

引用

页码：52 / 58

页数：7

共 13 条

[1] Gasser C., Gauthier E., Steck A., Siebenman R.E., Dechslin R., Hämolytisch-urämische Syndrome: bilaterale Nierenrindennekrosen bei akuten erworbenen hämolytischen Anämien, Schweiz Med Wochenschr, 38, pp. 905-909, (1955)
[2] Drummond K.N., Hemolytic uremic syndromethen and now, N Engl J Med, 312, pp. 116-118, (1985)
[3] Remuzzi G., HUS and TTP: variable expressions of a single entity, Kidney Int, 32, pp. 292-308, (1987)
[4] Habib R., Levy M., Gagnadoux M-F, Broyer M., Prognosis of the hemolytic uremic syndrome in children, Advances in nephrology, vol 2, pp. 99-128, (1982)
[5] Thoenes W., John H-D, Endotheliotropic (hemolytic) nephroangiopathy and its various manifestation forms (thrombotic microangiopathy, primary malignant nephrosclerosis, hemolytic-uremic syndrome), Klin Wochenschr, 58, pp. 173-184, (1980)
[6] Gianantonio C.A., Vitacco M., Mendilaharzu F., Gallo G.E., Sojo E.T., The hemolytic-uremic syndrome, Nephron, 11, pp. 174-192, (1973)
[7] Siegler R.L., Hemolytic uremic syndrome: clinical observations in the Southwest Pediatric Nephrology Study Group and laboratory findings from the University of Utah Health Sciences Center, Recent advances in pediatric nephrology, pp. 581-586, (1987)
[8] Argyle J.C., Pysher T.J., Silva F.G., A clinicopathologic study of 24 children with hemolytic uremic syndrome (HUS). Report of the Southwest Pediatric Nephrology Study Group, Lab Invest, 58, (1988)
[9] Pirani C.L., Salinas-Madrigal L., Koss M.N., Evaluation of percutaneous renal biopsy, Kidney pathology decennial, 1966–1977, pp. 109-163, (1975)
[10] A clinico-pathologic study of crescentic glomerulonephritis in 50 children, Kidney Int, 27, pp. 450-458, (1985)

← 1 2 →