ACQUIRED EXPRESSION OF HST-1 IN AN AUTONOMOUS SUBLINE (CHIBA SUBLINE-2) DERIVED FROM ANDROGEN-RESPONSIVE MOUSE MAMMARY-TUMOR (SHIONOGI CARCINOMA-115)

被引：6

作者：

AKAKURA, K

FURUYA, Y

SATO, N

KODAMA, T

TESHIMA, S

SHIMOSATO, Y

YOSHIDA, T

TERADA, M

SHIMAZAKI, J

机构：

[1] CHIBA UNIV,SCH MED,DEPT UROL,1-8-1 INOHANA,CHIBA 280,JAPAN

[2] NATL CANC CTR,RES INST,DIV PATHOL,CHUO KU,TOKYO 104,JAPAN

[3] NATL CANC CTR,RES INST,DIV GENET,CHUO KU,TOKYO 104,JAPAN

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1990年 / 81卷 / 6-7期

关键词：

Chiba Subline 2; hst‐1; int‐2; Shionogi Carcinoma 115;

D O I：

10.1111/j.1349-7006.1990.tb02606.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Since growth of Shionogi Carcinoma 115 (SC 115) and its autonomous subline (CS 2) were regulated by fibroblast growth factor‐like peptide, expression of int‐2 and hst‐1 was examined in these cell lines. Hybridization of genomic DNA with long terminal repeat of mouse mammary tumor virus (MMTV) revealed the same pattern of restriction fragments, showing the same integration of MMTV. Although weak expression of int‐2 was noticed in the two cells, clear expression of hst‐1 was seen only in CS 2 cultured with/without testosterone. It is suggested that autonomous growth of androgen‐unresponsive CS 2 is connected with expression of hst‐1. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：554 / 556

页数：3

共 23 条

[1] AN ONCOGENE ISOLATED BY TRANSFECTION OF KAPOSIS-SARCOMA DNA ENCODES A GROWTH-FACTOR THAT IS A MEMBER OF THE FGF FAMILY [J].