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EFFECT OF PSEUDOMONAS-AERUGINOSA-DERIVED PYOCYANIN AND 1-HYDROXYPHENAZINE ON PULMONARY MUCOCILIARY CLEARANCE MONITORED SCINTIGRAPHICALLY IN THE BABOON MODEL

被引：17
作者：
DORMEHL, I
RAS, G
TAYLOR, G
HUGO, N
机构：
[1] UNIV PRETORIA,DEPT INTERNAL MED,PRETORIA,SOUTH AFRICA
[2] HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT CLIN PHARMACOL,LONDON W12 0HS,ENGLAND
来源：
NUCLEAR MEDICINE AND BIOLOGY | 1991年 / 18卷 / 05期
关键词：
D O I：
10.1016/0883-2897(91)90105-T
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
The effect of products of the bacterium Pseudomonas aeruginosa on mucociliary lung clearance has been monitored in vivo in the baboon model by scintigraphy. Clearance was found to be inhibited by both 1-hydroxyphenazine and pyocyanin, and a dose-effect was illustrated by the former. This confirms previous in vitro results as well as results from work on guinea-pigs, and holds good prospects for the use of the baboon model under anesthesia in such investigations.
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页码：455 / &
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