LOCALIZATION OF THE VONHIPPEL-LINDAU DISEASE GENE TO A SMALL REGION OF CHROMOSOME-3

被引：133

作者：

HOSOE, S

BRAUCH, H

LATIF, F

GLENN, G

DANIEL, L

BALE, S

CHOYKE, P

GORIN, M

OLDFIELD, E

BERMAN, A

GOODMAN, J

ORCUTT, ML

HAMPSCH, K

DELISIO, J

MODI, W

MCBRIDE, W

ANGLARD, P

WEISS, G

WALTHER, MM

LINEHAN, WM

LERMAN, MI

ZBAR, B

机构：

[1] NCI,FREDERICK CANC RES & DEV FACIL IMMUNOBIOL LAB,BLDG 560,ROOM 12-71,FREDERICK,MD 21701

[2] NCI,ENVIRONM EPIDEMIOL BRANCH,BETHESDA,MD 20892

[3] NEI,CTR CLIN,DEPT DIAGNOST RADIOL,BETHESDA,MD 20892

[4] NEI,CLIN BRANCH,BETHESDA,MD 20892

[5] NINCDS,SURG NEUROL BRANCH,BETHESDA,MD 20892

[6] NINCDS,CTR CLIN,DEPT NURSING,BETHESDA,MD 20892

[7] PROGRAM RESOURCES INC,FREDERICK,MD 21701

[8] NCI,BIOCHEM LAB,BETHESDA,MD 20892

[9] NCI,SURG BRANCH,BETHESDA,MD 20892

来源：

GENOMICS | 1990年 / 8卷 / 04期

关键词：

D O I：

10.1016/0888-7543(90)90249-T

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We studied 25 families with von Hippel-Lindau disease (VHL) to locate VHL more precisely on chromosome 3. We found that VHL was linked to RAF1, confirming previous observations, and to two polymorphic DNA markers, D3S18 and D3S191. Multipoint linkage analysis indicated that the most likely location for VHL was in the interval between RAF1 and D3S18. D3S18 was located at 3p26. Genetic heterogeneity was not detected in this panel of von Hippel-Lindau disease families. The polymorphic markers RAF1, D3S18, and D3S191 should be useful in identifying asymptomatic gene carriers in VHL families and in guiding efforts at gene isolation. © 1990.

引用

页码：634 / 640

页数：7

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