SEX STEROID-BINDING PROTEIN INTERACTS WITH A SPECIFIC RECEPTOR ON HUMAN PREMENOPAUSAL ENDOMETRIUM MEMBRANE - MODULATING EFFECT OF ESTRADIOL

被引：36

作者：

FORTUNATI, N ^{[1
]}

FISSORE, F ^{[1
]}

FAZZARI, A ^{[1
]}

BERTA, L ^{[1
]}

GIUDICI, M ^{[1
]}

FRAIRIA, R ^{[1
]}

机构：

[1] OSPED INFERM BIELLA,SERV ANAT PATOL,BIELLA,ITALY

来源：

STEROIDS | 1991年 / 56卷 / 06期

关键词：

SEX STEROID-BINDING PROTEIN (SBP); MEMBRANE RECEPTOR; HUMAN PREMENOPAUSAL ENDOMETRIUM; SEX STEROIDS; SBP-MEMBRANE INTERACTION; ESTRADIOL;

D O I：

10.1016/0039-128X(91)90058-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sex steroid-binding protein receptor was detected on membranes prepared from human premenopausal endometrium. The binding of sex steroid-binding protein to membranes was specfic, saturable, and high affinity. Scatchard analysis showed the presence of two binding sites at different affinities. The addition of estradiol (10(-8) M) did not produce any inhibition of binding; indeed, it resulted in a modification of binding characteristics. The demonstration of sex steroid-binding protein receptor on membranes of human premenopausal endometrium indicates that the expression of receptor on membranes is not an effect of estrogen over stimulation on target tissues. Estradiol could not act as a modulating factor of the binding, probably reflecting the sensitivity of tissues to different steroids.

引用

页码：341 / 346

页数：6

共 18 条

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