INDIVIDUAL VARIABILITY IN THE TRANSLATIONAL REGULATION OF RIBOSOMAL-PROTEIN SYNTHESIS IN XENOPUS-LAEVIS

被引：8

作者：

BAGNI, C ^{[1
]}

MARIOTTINI, P ^{[1
]}

TERRENATO, L ^{[1
]}

AMALDI, F ^{[1
]}

机构：

[1] UNIV ROMA TOR VERGATA,DIPARTIMENTO BIOL,VIA E CARNEVALE,I-00173 ROME,ITALY

来源：

MOLECULAR & GENERAL GENETICS | 1992年 / 234卷 / 01期

关键词：

XENOPUS DEVELOPMENT; RIBOSOMAL PROTEINS; TRANSLATIONAL REGULATION;

D O I：

10.1007/BF00272345

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ribosomal protein synthesis is regulated by controlling the fraction of mRNA associated with polysomes. It is known that this value changes in different developmental stages during Xenopus embryogenesis or, more generally, with changing cell growth conditions. We present here an analysis of the proportion of mRNA loaded on polysomes, carried out with probes for five different ribosomal proteins on several batches of Xenopus embryos obtained from different individuals. The results obtained indicate the existence of probe-dependent and individual differences, which reflect genetic variations in the cis- and trans-acting regulatory elements responsible for translational regulation. The fraction of ribosomal protein mRNA loaded onto polysomes can be used as an index of an individual's capacity for ribosome production.

引用

页码：60 / 64

页数：5

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