THE RELATIONSHIP BETWEEN SURAL NERVE MORPHOMETRIC FINDINGS AND MEASURES OF PERIPHERAL-NERVE FUNCTION IN MILD DIABETIC NEUROPATHY

被引：76

作者：

VEVES, A ^{[1
]}

MALIK, RA ^{[1
]}

LYE, RH ^{[1
]}

MASSON, EA ^{[1
]}

SHARMA, AK ^{[1
]}

SCHADY, W ^{[1
]}

BOULTON, AJM ^{[1
]}

机构：

[1] MANCHESTER ROYAL INFIRM,CTR DIABET,MANCHESTER M13 9WL,LANCS,ENGLAND

来源：

DIABETIC MEDICINE | 1991年 / 8卷 / 10期

关键词：

DIABETIC NEUROPATHY; ELECTROPHYSIOLOGY; SURAL NERVE BIOPSIES;

D O I：

10.1111/j.1464-5491.1991.tb01530.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The morphological findings in sural nerve biopsy specimens from 15 diabetic patients with mild neuropathy were compared with control biopsies from eight non-neuropathic, non-diabetic subjects, and correlations were sought with electrophysiological studies and quantitative sensory tests for vibration, thermal, and current perception thresholds. Myelinated fibre density was reduced compared with control biopsies (4042 +/- 2090 (+/- SD) vs 6800 +/- 1100 mm-2; p < 0.01). A strong correlation existed between myelinated fibre density and sural sensory conduction velocity (r = 0.84, p < 0.001), sural action potential amplitude (r = 0.74, p < 0.001), peroneal motor conduction velocity (r = 0.58, p < 0.02), and median sensory amplitude (r = 0.64, p < 0.01) but there was no correlation between myelinated fibre density and any quantitative sensory test. We conclude that conventional electrophysiological tests in the lower limb are reliable surrogate measures for structural abnormalities in early diabetic neuropathy.

引用

页码：917 / 921

页数：5

共 31 条

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