INDUCTION OF TUBULORETICULAR STRUCTURES IN CULTURED HUMAN ENDOTHELIAL-CELLS BY RECOMBINANT INTERFERON-ALFA AND INTERFERON-BETA

被引：19

作者：

HAMMAR, SP ^{[1
]}

LUU, JY ^{[1
]}

BOCKUS, DE ^{[1
]}

REMINGTON, FL ^{[1
]}

LUU, JW ^{[1
]}

FRIEDMAN, S ^{[1
]}

BEAN, MA ^{[1
]}

机构：

[1] VIRGINIA MASON RES CTR,SEATTLE,WA 98101

来源：

ULTRASTRUCTURAL PATHOLOGY | 1992年 / 16卷 / 1-2期

关键词：

ENDOTHELIAL CELLS; INTERFERON; TUBULORETICULAR STRUCTURES;

D O I：

10.3109/01913129209074562

中图分类号：

TH742 [显微镜];

学科分类号：

摘要：

Tubuloreticular structures were induced in human umbilical vein endothelial cells cultured in media containing recombinant interferon alfa and beta but not in media containing recombinant interferon gamma or other agents that induce interferon, such as 5-bromodeoxyuridine or polyinosinic-polycytidylic acid. Recombinant interferon beta induced tubuloreticular structures in endothelial cells at a lower concentration and in a greater percentage of cell sections than recombinant interferon alfa. This report of tubuloreticular structures being induced in vitro in nonlymphoid cells provides evidence that interferon is the substance that causes the formation of tubuloreticular structures in endothelial cells in vivo.

引用

页码：211 / 218

页数：8

共 31 条

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[4]

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