IMPLICATION OF C-5, C-6 UNSATURATION AS A KEY STRUCTURAL FACTOR IN STEROIDAL ALKALOID-INDUCED MAMMALIAN TERATOGENESIS

被引：23

作者：

GAFFIELD, W ^{[1
]}

KEELER, RF ^{[1
]}

机构：

[1] USDA ARS,POISONOUS PLANT RES LAB,LOGAN,UT 84321

来源：

EXPERIENTIA | 1993年 / 49卷 / 10期

关键词：

SOLANUM ALKALOIDS; VERATRUM ALKALOIDS; TERATOGENESIS; CRANIOFACIAL MALFORMATIONS; HAMSTER;

D O I：

10.1007/BF01952611

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Hamster teratogenicity induced upon oral administration of steroidal alkaloids (solanidanes, spirosolanes and jervanes) appears to relate very closely to the presence or absence of C-5, C-6 unsaturation in the alkaloid, which may be more important than molecular configuration at C-22 and placement of the nitrogen atom with regard to the plane of the steroid.

引用

页码：922 / 924

页数：3

共 14 条

[1] LESIONS OF POTATO SPROUT AND EXTRACTED POTATO SPROUT ALKALOID TOXICITY IN SYRIAN-HAMSTERS [J].