STRUCTURAL ALIGNMENT OF GLOBINS, PHYCOCYANINS AND COLICIN-A

被引：76

作者：

HOLM, L

SANDER, C

机构：

[1] Protein Design Group, European Molecular Biology Laboratory

来源：

FEBS LETTERS | 1993年 / 315卷 / 03期

关键词：

GLOBIN FOLD; PHYCOCYANIN; COLICIN-A; STRUCTURAL SIMILARITY; FOLDING MOTIF; CONVERGENT EVOLUTION;

D O I：

10.1016/0014-5793(93)81183-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A database search employing a novel algorithm for protein structure comparison by alignment of distance matrices has revealed a striking resemblance between the tertiary structures of the bacterial toxin colicin A and globins. The globin-like domain in colicin A contains all elements essential for the toxin's lethal ionophoric activity. The structural similarity between colicin A and globins is comparable to that between globins and phycocyanins. This suggests that these three protein families, which have unrelated sequences and different functional contexts, are an example of physical convergence to a stable folding motif, the three-on-three helical sandwich.

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收藏

页码：301 / 306

页数：6

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