CDC2-RELATED PROTEIN-KINASES AND CELL-CYCLE CONTROL IN TRYPANOSOMATIDS

被引：42

作者：

MOTTRAM, JC

机构：

[1] Wellcome Unit of Molecular Parasitology, Institute of Genetics, University of Glasgow, Glasgow, GII 5JS, Church Street

来源：

PARASITOLOGY TODAY | 1994年 / 10卷 / 07期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0169-4758(94)90136-8

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The molecular mechanisms that control the cell cycle have been studied extensively in yeast and higher eukaryotes. Investigations have centred on the cyclin-dependent kinase family of serine/threonine protein kinases, the best characterized of which is cdc2, a key regulatory element in the control of mitosis. Cell cycle control plays an important role in trypanosomes and Leishmania, not only in cellular proliferation, but also in the developmental system that controls the transfer of the parasite between hosts. In this review, Jeremy Mottram compares the family of trypanosome cdc2-related kinases with that of yeast and the higher eukaryotes.

引用

页码：253 / 257

页数：5

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