FACILITATION OF RETINAL FUNCTION RECOVERY BY NATURAL-PRODUCTS AFTER TEMPORARY ISCHEMIC OCCLUSION OF CENTRAL RETINAL ARTERY

被引：16

作者：

CHIOU, GCY

LI, BH

WANG, MS

机构：

[1] Institute of Ocular Pharmacology, Department of Medical Pharmacology and Toxicology, Texas A&M University Health Science Center, Texas, College Station

[2] Department of Phytochemistry, China Pharmaceutical University, Nanjing

来源：

JOURNAL OF OCULAR PHARMACOLOGY | 1994年 / 10卷 / 02期

关键词：

D O I：

10.1089/jop.1994.10.493

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The b-wave of electroretinogram (ERG) was used as an indicator of the retinal function in this research to study the facilitation of retinal function recovery by some natural products isolated from medicinal plants. The retinal ischemia was induced by occlusion of the central retinal artery. It was found that the recovery of b-waves was limited to approximately 30-37% in control animals, whereas the b-wave recovery was doubled by natural products, including scoparone, corylifolinin and EGCG (epigallocatechin-3-0-gallate). Lespedeza flavanone A had biphasic action by suppressing the b-wave recovery below control level initially, then enhancing the b-wave recovery over the control rate later. These results indicate that some natural products could be used for the treatment of ischemic retinopathy.

引用

页码：493 / 498

页数：6

共 8 条

[1]

Lierman T.L., Building a Healthy America, (1987)

[2]

O'Connor P.R., Retinal Vascular Disease, (1974)

[3]

Jiangsu New Medical College, (1975)

[4]

Crosson C.E., Willis J.A., Potter D.E., Effect of the calcium antagonist, nifedipine, on the ischemie retinal dysfunction, J. Ocular Pharmacol., 6, pp. 293-299, (1990)

[5]

Chiou G.C.Y., Li B.H.P., Effects of dopamine antagonists on retinal b-wave recovery after retinal ischemia, J. Ocular Pharmacol., 9, pp. 179-185, (1993)

[6]

Yoon Y.H., Marmor M.F., Dextromethorphan protects retina against ischemie injury in vivo, Arch. Ophthalmo1., 107, pp. 409-411, (1989)

[7]

Gupta L.Y., Marmor M.F., Mannitol, dextromethorphan and catalase minimize ischemie damage to retinal pigment epithelium and retina, Arch. Ophthalmo1., 111, pp. 384-388, (1993)

[8]

Destro M., Gragoudis E.S., Arterial Occlusions, pp. 731-733, (1993)

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