HEMATOPORPHYRIN DERIVATIVE (PHOTOFRIN((R))) PHOTODYNAMIC-ACTION ON CA2+ TRANSPORT IN MONKEY KIDNEY-CELLS (CV-1)

被引：16

作者：

DELLINGER, M

RICCHELLI, F

MORENO, G

SALET, C

机构：

[1] MUSEUM NATL HIST NAT,INSERM,U201,BIOPHYS LAB,F-75231 PARIS 05,FRANCE

[2] MUSEUM NATL HIST NAT,CNRS,URA 481,F-75231 PARIS 05,FRANCE

[3] UNIV PADUA,CNR,CTR MET PROT,DIPARTIMENTO BIOL,PADUA,ITALY

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1994年 / 60卷 / 04期

关键词：

D O I：

10.1111/j.1751-1097.1994.tb05117.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

After 24 h incubation with Photofrin(R) (PF), photodynamic action has been studied on Ca2+ transport in CV-1 cells. A moderate increase of the cytosolic free Ca2+ concentration [Ca2+](i) is observed immediately after a dose of irradiation which yields a survival rate of less than 5% at 48 h. In parallel, studies on digitonin-permeabilized cells indicate that such a treatment inhibits endoplasmic reticulum Ca2+ uptake with few alterations of this process in mitochondria. In contrast, ADP-stimulated respiration is impeded and intracellular ATP level decreases. It is suggested that direct damage to endoplasmic reticulum as well as mitochondrial disturbance are the primary mechanisms responsible for a nontransient elevation of[Ca2+](i) preceding cell death.

引用

页码：368 / 372

页数：5

共 34 条

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