AMPHIPHILIC VINYL-POLYMERS EFFECTIVELY PROLONG LIPOSOME CIRCULATION TIME IN-VIVO

被引：193

作者：

TORCHILIN, VP ^{[1
]}

SHTILMAN, MI ^{[1
]}

TRUBETSKOY, VS ^{[1
]}

WHITEMAN, K ^{[1
]}

MILSTEIN, AM ^{[1
]}

机构：

[1] DI MENDELEEV UNIV CHEM TECHNOL,MOSCOW 125190,RUSSIA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 1994年 / 1195卷 / 01期

关键词：

DRUG CARRIER; LONG-CIRCULATING LIPOSOME; AMPHIPHILIC POLYMER; POLYACRYLAMIDE; POLY(VINYL PYRROLIDONE); BIODISTRIBUTION;

D O I：

10.1016/0005-2736(94)90025-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Newly synthesized amphiphilic polyacrylamide and poly(vinyl pyrrolidone), single terminus-modified with long-chain fatty acyl groups, are able to incorporate into the liposomal membrane, and similar to poly(ethylene glycol) prolong liposome circulation in vivo and decrease liposome accumulation in the liver. Protective efficacy of modified polymers increases with the increase in the length of acyl moiety and decreases for higher molecular weight polymers. The data on amphiphilic polymer-modified liposome biodistribution are presented.

引用

页码：181 / 184

页数：4

共 12 条

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