BIOTIN BASICITY

被引：20

作者：

CAPLOW, M

机构：

[1] Department of Biochemistry, Yale University, Connecticut 06510, New Haven

来源：

BIOCHEMISTRY | 1969年 / 8卷 / 06期

关键词：

D O I：

10.1021/bi00834a061

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The pKa′s in aqueous solution of biotin, desthiobiotin, imidazolidone, and dimethylurea are -1.13, -0.97, -1.05, and -0.20, respectively. From this it may be concluded that protonation of biotin occurs on the ureido group, presumably on the carbonyl oxygen atom. The absence of any measurable interaction between the ureido system and the thioether linkage of biotin suggests that the sulfur atom does not play a significant role in enzymatic transcarboxylation from N-carboxybiotin. © 1969, American Chemical Society. All rights reserved.

引用

页码：2656 / &

共 13 条

[1] QUANTITATIVE COMPARISONS OF WEAK ORGANIC BASES [J].