MSG EFFECTS ON BETA-ENDORPHIN AND ALPHA-MSH IN THE HYPOTHALAMUS AND CAUDAL MEDULLA

被引:28
作者
ALESSI, NE [1 ]
QUINLAN, P [1 ]
KHACHATURIAN, H [1 ]
机构
[1] UNIV TENNESSEE, CTR HLTH SCI, COLL MED, DEPT ANAT & NEUROBIOL, MEMPHIS, TN 38163 USA
关键词
D O I
10.1016/0196-9781(88)90108-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Monosodium glutamate (MSG) was given to neonatal male rats to determine its effects on neurons containing beta-endorphin (.beta.-END) and alpha-melanocyte stimulating hormone (.alpha.-MSH) within the basal hypothalamus (arcuate nucleus) and caudal medulla [nucleus tractus solitarius (NTS)] and on the levels of .beta.-END and .alpha.-MSH within these areas. Immunocytochemical studies demonstrated a reduction in the number of cells within the medial hypothalamic area (arcuate nucleus) among MSG-treated animals versus saline controls. MSG did not reduce the number of cell bodies within the caudal medulla (NTS). MSG significantly reduced .beta.-END and .alpha.-MSH immunoreactive levels in the basal hypothalamus as determined by radioimmunoassay. Whereas a significant reduction in the level of .beta.-END occurred in the ventral caudal medulla (VCM), none occurred in the dorsal caudal medulla (DCM). In contrast, levels of .alpha.-MSH increased significantly in the DCM among animals receiving MSG compared to control animals. This study documents the contribution of beta-endorphin containing neurons of the basal hypothalamus to areas of the caudal medulla. The effect of MSG on beta-endorphin and .alpha.-MSH neurons in these areas and their differential effects on levels in the caudal medulla area raises questions about the sites of origin of these peptides.
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页码:689 / 695
页数:7
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