TRANSPLACENTAL INDUCTION OF MEMBRANOUS NEPHROPATHY IN A NEONATE

被引：14

作者：

NAUTA, J

DEHEER, E

BALDWIN, WM

TENKATE, FJW

VANDERHEIJDEN, AJ

WOLFF, ED

机构：

[1] Department of Paediatrics, Division of Nephrology, Sophia Children's Hospital, Erasmus University Medical School, Rotterdam

[2] Department of Pathology, University of Leiden, Leiden

[3] Department of Pathology, Duke Medical Center, Durham, North Carolina

[4] Department of Pathology, Erasmus University Medical School, Rotterdam

来源：

PEDIATRIC NEPHROLOGY | 1990年 / 4卷 / 02期

关键词：

Glomerulonephritis; Kidney failure; Maternal-fetal exchange; Pathophysiology;

D O I：

10.1007/BF00858820

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We report a case of renal failure in a newborn infant due to membranous glomerulonephritis. The patient was anuric in the first 3 weeks of life, after which renal function recovered. The serum of the mother contained IgG antibodies which reacted with tubular brush borders and glomeruli of adult and fetal human kidneys. Reactivity with renal epithelium from human kidneys was detected. We suggest that a transplacental, passive Heymann nephritis-like mechanism was the pathogenesis of the neonate's symptoms, although the antigen(s) involved was shown not to be gp 330 or any of the renal antigens known to be involved in experimental nephropathies. © 1990 IPNA.

引用

页码：111 / 116

页数：6

共 30 条

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