DETERMINATION OF ISOSORBIDE DINITRATE IN PHARMACEUTICAL PRODUCTS BY HPLC

被引：8

作者：

CARLSON, M

THOMPSON, RD

SNELL, RP

机构：

[1] U.S. Food and Drug Administration, Pharmaceutical Analysis Section, Minneapolis, MN 55401, United States

来源：

JOURNAL OF CHROMATOGRAPHIC SCIENCE | 1988年 / 26卷 / 11期

关键词：

Chromatographic Analysis--Liquid - Esters - Organic Compounds--Chromatographic Analysis;

D O I：

10.1093/chromsci/26.11.574

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A high-performance liquid chromatographic (HPLC) assay for isosorbide dinitrate in pharmaceutical formulations is described. The method employs a reversed-phase C18 column with a mobile phase containing methanol/water/acetate buffer and is specific for isosorbide dinitrate with respect to its 2- and 5-mononitrate degradation products and other organic polynitrate esters. The method is applicable to the analysis of the diluted bulk drug and dosage forms, including sublingual, oral, chewable, and timed-release preparations.

引用

页码：574 / 578

页数：5

共 14 条

[1]

BHALLA H L, 1984, Indian Drugs, V21, P158

[2]

BHALLA HL, 1985, INDIAN DRUGS, V22, P541

[3] SEPARATION AND QUANTITATION OF POLYNITRATE ESTERS IN PHARMACEUTICAL PREPARATIONS BY REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].