DNA PLOIDY, TUMOR SITE, AND PROGNOSIS IN COLORECTAL-CANCER - A FLOW CYTOMETRIC STUDY OF PARAFFIN-EMBEDDED TISSUE

被引：31

作者：

HALVORSEN, TB

JOHANNESEN, E

机构：

[1] Dept. of Pathology, Trondheim Regional, University Hospital, Trondheim

来源：

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY | 1990年 / 25卷 / 02期

关键词：

Colorectal cancer; Flow cytometrv; Paraffin-embedded tissue; Prognosis;

D O I：

10.3109/00365529009107935

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

DNA ploidy patterns were studied by flow cytometry in nuclear suspensions from 149 paraffin-embedded colorectal adenocarcinomas. The DNA ploidy of rectal tumours was not significantly different from that of colonic tumours. Patients with DNA diploid tumours had a significant survival advantage compared with patients with non-diploid tumours, but DNA ploidy did not confer any significant additional prognostic information when turnour site, Dukes's stage, the invasiveness of the tumour, and the number of lymph node metastases were adjusted for in a proportional hazards regression analysis (Cox). It is concluded that DNA ploidy does not contribute significantly to the explanation of why patients with rectal cancer have a poorer prognosis than those with colonic cancer. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：141 / 148

页数：8

共 42 条

[1] THE INFLUENCE OF TUMOR-CELL DNA ABNORMALITIES ON SURVIVAL IN COLORECTAL-CANCER [J].