DISTRIBUTION OF PHORBOL ESTER TPA-INDUCED STRUCTURAL CHROMOSOMAL-ABERRATIONS IN HELA-CELLS

被引：8

作者：

FARBER, B ^{[1
]}

KINZEL, V ^{[1
]}

机构：

[1] GERMAN CANC RES CTR,INST EXPTL PATHOL,NEUENHEIMER FELD 280,W-6900 HEIDELBERG 1,GERMANY

来源：

CARCINOGENESIS | 1990年 / 11卷 / 11期

关键词：

D O I：

10.1093/carcin/11.11.2067

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In order to gain further insight into the mechanism of clastogenic action of the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA), the localization and distribution of structural chromosomal aberrations on HeLa chromosomes was investigated. We have shown by the G-banding technique that TPA-induced chromosomal aberrations in HeLa cells have practically the same distribution as that occurring spontaneously in control cultures. About two-thirds of the breakpoints are located in areas of known fragile sites; about one-third is located in regions near known oncogenes. The tumor promoter TPA thus appears to enhance pre-existing mechanisms of an 'endogeneous' clastogenesis. © 1990 Oxford University Press.

引用

页码：2067 / 2070

页数：4

共 17 条

[1] MECHANISMS OF CHROMOSOMAL ABERRATION PRODUCTION .3. CHEMICALS AND IONIZING-RADIATION [J].

BENDER, MA ;

GRIGGS, HG ;

BEDFORD, JS .

MUTATION RESEARCH, 1974, 23 (02) :197-212

[2] TUMOR PROMOTER 12-O-TETRADECANOYLPHORBOL-13-ACETATE (TPA)-INDUCED CHROMOSOME-ABERRATIONS IN MOUSE KERATINOCYTE CELL-LINES - A POSSIBLE GENETIC MECHANISM OF TUMOR PROMOTION [J].

DZARLIEVAPETRUSEVSKA, RT ;

FUSENIG, NE .

CARCINOGENESIS, 1985, 6 (10) :1447-1456

[3] CYTOGENETIC EFFECTS CAUSED BY PHORBOL ESTER TUMOR PROMOTERS IN HELA-CELLS - MECHANISTIC ASPECTS [J].

FARBER, B ;

PETRUSEVSKA, RT ;

FUSENIG, NE ;

KINZEL, V .

CARCINOGENESIS, 1989, 10 (12) :2345-2350

[4] PARTIAL INVERSION OF THE INITIATION-PROMOTION SEQUENCE OF MULTISTAGE TUMORIGENESIS IN THE SKIN OF NMRI MICE [J].

FURSTENBERGER, G ;

KINZEL, V ;

SCHWARZ, M ;

MARKS, F .

SCIENCE, 1985, 230 (4721) :76-78

[5]

FURSTENBERGER G, 1987, PROSTAGLANDINS CANCE, P48

[6] NEW COMMON FRAGILE SITES [J].

HECHT, F ;

TAJARA, EH ;

LOCKWOOD, D ;

SANDBERG, AA ;

HECHT, BK .

CANCER GENETICS AND CYTOGENETICS, 1988, 33 (01) :1-9

[7]

KIHLMAN BA, 1966, ACTIONS CHEM DIVIDIN

[8]

KINZEL V, 1981, CANCER RES, V41, P300

[9] TUMOR PROMOTER TPA MIMICS IRRADIATION EFFECTS ON THE CELL-CYCLE OF HELA-CELLS [J].

KINZEL, V ;

RICHARDS, J ;

STOHR, M .

SCIENCE, 1980, 210 (4468) :429-431

[10]

KINZEL V, 1979, CANCER RES, V39, P2743

← 1 2 →