CYTOGENETIC EFFECT OF METHOTREXATE ON HUMAN-CELLS INVIVO - COMPARISON BETWEEN RESULTS OBTAINED BY CHROMOSOME-STUDIES ON BONE-MARROW CELLS AND BLOOD-LYMPHOCYTES AND BY THE MICRONUCLEUS TEST

被引：80

作者：

JENSEN, MK

NYFORS, A

机构：

[1] FINSEN INST,DEPT DERMATOL,DK-2100 COPENHAGEN,DENMARK

[2] UNIV BERGEN,HAUKELAND HOSP,DEPT DERMATOL,N-5016 BERGEN,NORWAY

来源：

MUTATION RESEARCH | 1979年 / 64卷 / 05期

关键词：

D O I：

10.1016/0165-1161(79)90126-2

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Cytogenetic studies were performed in 22 patients treated with methotrexate (MTX). In some patients, metaphases from both bone-marrow cells and peripheral blood cells were studied. In the bone-marrow preparations an increased number of structural chromosomal aberrations was present, whereas abnormalities were not observed in the peripheral blood cells. An examination of the bone-marrow chromosomes must therefore be included in the study of the possible chromosome-breaking effect of chemical agents. The results obtained with the micronucleus test and chromosome studies were compared in 10 patients treated with MTX. The micronucleus test was more sensitive than the chromosome analysis as regards the clastogenic effect of MTX. © 1979.

引用

页码：339 / 343

页数：5

共 17 条

[1] CHEMICAL MUTAGENESIS IN MAMMALS - CHINESE HAMSTER BONE MARROW AS AN IN-VIVO TEST SYSTEM - HEMATOLOGICAL FINDINGS AFTER TREATMENT WITH TRENIMON [J].

BOLLER, K ;

SCHMID, W .

HUMANGENETIK, 1970, 11 (01) :35-&

[2] RELATIONSHIP BETWEEN EXPERIMENTAL RESULTS IN MAMMALS AND MAN .1. CYTOGENETIC ANALYSIS OF BONE-MARROW INJURY INDUCED BY A SINGLE DOSE OF CYCLOPHOSPHAMIDE [J].

GOETZ, P ;

SRAM, RJ ;

DOHNALOVA, J .

MUTATION RESEARCH, 1975, 31 (04) :247-254

[3] RAPID IN-VIVO TEST FOR CHROMOSOMAL DAMAGE [J].

HEDDLE, JA .

MUTATION RESEARCH, 1973, 18 (02) :187-190

[4]

HERSH EM, 1967, CANCER RES, V27, P98

[5]

KROGHJENSEN M, 1977, MUTAT RES, V45, P249

[6]

KROGHJENSEN M, 1967, ACTA MED SCAND, V182, P445

[7]

KROGHJENSEN M, 1971, MUTAT RES, V12, P91

[8]

KROGHJENSEN M, 1972, ADV ANTIMICROBIAL AN

[9]

KROGHJENSEN M, 1976, DAN MED B, V23, P152

[10]

LAMPOTANG PR, 1968, SCAND J HAEMATOL, V5, P158

← 1 2 →