DIFFERENTIAL RESPONSE OF MYOFIBRILS AND 10-NM FILAMENTS TO A CO-CARCINOGEN

被引：24

作者：

TOYAMA, Y

WEST, CM

HOLTZER, H

机构：

[1] Department of Anatomy, School of Medicine, University of Pennsylvania, Philadelphia

来源：

AMERICAN JOURNAL OF ANATOMY | 1979年 / 156卷 / 01期

关键词：

D O I：

10.1002/aja.1001560114

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Multinucleated myotubes containing large numbers of striated myofibrils and large numbers of longitudinally‐oriented 10‐nm filaments were treated with the cocarcinogen phorbol‐12‐myristate‐13‐acetate (PMA) for 24, 48 or 72 hours. The inhibitory effects of PMA on the accumulation of myofibrils was evident within 24 hours, and by 72 hours virtually all striated myofibrils had disappeared. In contrast, the density of the 10‐nm filaments was greatly enhanced in these myofibrildepleted myotubes. These effects were not due to a generalized cytotoxicity, for PMA stimulated the replication of the presumptive myoblasts and fibroblasts present in these cultures. 24 hours after removing the PMA, these myotubes assembled a new set of striated myofibrils and the density of 10‐nm filaments diminished proportionately. Copyright © 1979 Wiley‐Liss, Inc.

引用

页码：131 / 137

页数：7

共 12 条

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