NOVEL TRANSLOCATIONS IN ACUTE NONLYMPHOCYTIC LEUKEMIA - 2 CASES INVOLVING CHROMOSOME-21, BAND-Q22

被引：11

作者：

PETERS, GB ^{[1
]}

DALE, BM ^{[1
]}

SAGE, RE ^{[1
]}

FORD, JH ^{[1
]}

机构：

[1] QUEEN ELIZABETH HOSP,DEPT HAEMATOL ONCOL,WOODVILLE,SA 5011,AUSTRALIA

来源：

CANCER GENETICS AND CYTOGENETICS | 1990年 / 44卷 / 01期

关键词：

D O I：

10.1016/0165-4608(90)90202-L

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We present two cases in which translocations involving 21q22 were found at presentation in acute nonlymphocytic leukemia (ANLL). The first of these translocations, t(3;21)(q26-q27;q22), is previously unknown in ANLL [1], but appears indistinguishable from that reportedly associated with Philadelphia-positive chronic myelogenous leukemia [2]. The second case involves t(15;21)(q21-q22;q22), a translocation previously undescribed in ANLL [1,3]. Both of these exchanges involve 21q22 plus another chromosome region associated with leukemogenesis. We attempted to interrelate these cytogenetic data with the oncogenic significance of 21q22. © 1990.

引用

页码：99 / 105

页数：7

共 19 条

[1] CRITERIA FOR THE DIAGNOSIS OF ACUTE-LEUKEMIA OF MEGAKARYOCYTE LINEAGE (M7) - A REPORT OF THE FRENCH-AMERICAN-BRITISH COOPERATIVE GROUP [J].

BENNETT, JM ;

CATOVSKY, D ;

DANIEL, MT ;

FLANDRIN, G ;

GALTON, DAG ;

GRALNICK, HR ;

SULTAN, C .

ANNALS OF INTERNAL MEDICINE, 1985, 103 (03) :460-462

[2] CYTOGENETIC STUDIES ON 519 CONSECUTIVE DENOVO ACUTE NONLYMPHOCYTIC LEUKEMIAS [J].

BERGER, R ;

FLANDRIN, G ;

BERNHEIM, A ;

LECONIAT, M ;

VECCHIONE, D ;

PACOT, A ;

DERRE, J ;

DANIEL, MT ;

VALENSI, F ;

SIGAUX, F ;

OCHOANOGUERA, ME .

CANCER GENETICS AND CYTOGENETICS, 1987, 29 (01) :9-21

[3]

COYLE T, 1987, CYTOGENET CELL GENET, V46, P600

[4] ISOLATION AND ANALYSIS OF THE 21Q+ CHROMOSOME IN THE ACUTE MYELOGENOUS LEUKEMIA 8-21 TRANSLOCATION - EVIDENCE THAT C-MOS IS NOT TRANSLOCATED [J].

DRABKIN, HA ;

DIAZ, M ;

BRADLEY, CM ;

LEBEAU, MM ;

ROWLEY, JD ;

PATTERSON, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (02) :464-468

[5]

DREAZEN O, 1987, LANCET, V1, P1402

[6]

HAYHOE FGJ, 1989, BONE MARROW TRANSPL, V4, P70

[7] SECONDARY CHROMOSOME-ABERRATIONS IN THE ACUTE LEUKEMIAS [J].

HEIM, S ;

MITELMAN, F .

CANCER GENETICS AND CYTOGENETICS, 1986, 22 (04) :331-338

[8] LOSS OF THE Y-CHROMOSOME IN ACUTE MYELOGENOUS LEUKEMIA - A REPORT OF 13 PATIENTS [J].

HOLMES, RI ;

KEATING, MJ ;

CORK, A ;

TRUJILLO, JM ;

MCCREDIE, KB ;

FREIREICH, EJ .

CANCER GENETICS AND CYTOGENETICS, 1985, 17 (03) :269-278

[9] CHROMOSOMES IN ACUTE LYMPHOCYTIC-LEUKEMIA [J].

HOSSFELD, DK .

CANCER GENETICS AND CYTOGENETICS, 1987, 26 (01) :59-64

[10] A 2-STEP TRANS(4-DER(15)) TRANS(15-17) COMPLEX TRANSLOCATION IN AN ACUTE PROMYELOCYTIC LEUKEMIA AND REVIEW OF THE LITERATURE [J].

HURET, JL ;

COUET, D ;

GUILHOT, F ;

BRIZARD, A ;

TANZER, J .

LEUKEMIA RESEARCH, 1987, 11 (08) :761-&

← 1 2 →