SHORT COURSE OF AEROSOL PENTAMIDINE AS TREATMENT OF PNEUMOCYSTIS-CARINII PNEUMONIA IN AIDS

被引：4

作者：

FLAMHOLC, L

HAIDL, S

WESTIN, E

PRELLNER, T

机构：

[1] Department of Infectious Diseases, Malmö General Hospital, University of Lund, Malmö

来源：

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES | 1991年 / 23卷 / 03期

关键词：

D O I：

10.3109/00365549109024313

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Since July 1987, 20 HIV-positive patients with Pneumocystis carinii pneumonia (PCP) admitted to the Department of Infectious Diseases, Malmo General Hospital, Sweden have been treated with 10 consecutive days of aerosol pentamidine as sole antimicrobial therapy in a prospective open non-controlled trial. 16 patients (80%) responded to 10 days of 400 mg aerosol pentamidine daily. One patient responded after a prolonged treatment, one patient received simultaneous trimethoprim-sulfamethoxazole due to lack of improvement during aerosol therapy. Two patients died 26 and 41 days after initiation of treatment. No systemic side effects occurred. In conclusion, we found that 10 days of aerosol pentamidine may be a safe and effective treatment of PCP. Controlled studies are needed.

引用

收藏

页码：293 / 298

页数：6

相关论文

共 20 条

[1] TRIMETREXATE FOR THE TREATMENT OF PNEUMOCYSTIS-CARINII PNEUMONIA IN PATIENTS WITH ACQUIRED-IMMUNODEFICIENCY-SYNDROME [J].

ALLEGRA, CJ ;

CHABNER, BA ;

TUAZON, CU ;

OGATAARAKAKI, D ;

BAIRD, B ;

DRAKE, JC ;

SIMMONS, JT ;

LACK, EE ;

SHELHAMER, JH ;

BALIS, F ;

WALKER, R ;

KOVACS, JA ;

LANE, HC ;

MASUR, H .

NEW ENGLAND JOURNAL OF MEDICINE, 1987, 317 (16) :978-985

[2] A CONTROLLED TRIAL OF EARLY ADJUNCTIVE TREATMENT WITH CORTICOSTEROIDS FOR PNEUMOCYSTIS-CARINII PNEUMONIA IN THE ACQUIRED-IMMUNODEFICIENCY-SYNDROME [J].

BOZZETTE, SA ;

SATTLER, FR ;

CHIU, J ;

WU, AW ;

GLUCKSTEIN, D ;

KEMPER, C ;

BARTOK, A ;

NIOSI, J ;

ABRAMSON, I ;

COFFMAN, J ;

HUGHLETT, C ;

LOYA, R ;

CASSENS, B ;

AKIL, B ;

MENG, TC ;

BOYLEN, CT ;

NIELSEN, D ;

RICHMAN, DD ;

TILLES, JG ;

LEEDOM, J ;

MCCUTCHAN, JA .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (21) :1451-1457

[3] INTRAVENOUS OR INHALED PENTAMIDINE FOR TREATING PNEUMOCYSTIS-CARINII PNEUMONIA IN AIDS - A RANDOMIZED TRIAL [J].

CONTE, JE ;

CHERNOFF, D ;

FEIGAL, DW ;

JOSEPH, P ;

MCDONALD, C ;

GOLDEN, JA .

ANNALS OF INTERNAL MEDICINE, 1990, 113 (03) :203-209

[4] OUTPUT CHARACTERISTICS FROM 3 MEDICAL NEBULIZERS [J].

DAHLBACK, M ;

NERBRINK, O ;

ARBORELIUS, M ;

HANSSON, HC .

JOURNAL OF AEROSOL SCIENCE, 1986, 17 (03) :563-564

[5] PERSISTENCE OF PNEUMOCYSTIS-CARINII PNEUMONIA IN THE ACQUIRED IMMUNODEFICIENCY SYNDROME - EVALUATION OF THERAPY BY FOLLOW-UP TRANS-BRONCHIAL LUNG-BIOPSY [J].

DELORENZO, LJ ;

MAGUIRE, GP ;

WORMSER, GP ;

DAVIDIAN, MM ;

STONE, DJ .

CHEST, 1985, 88 (01) :79-83

[6] DISTRIBUTION OF PENTAMIDINE IN PATIENTS WITH AIDS [J].

DONNELLY, H ;

BERNARD, EM ;

ROTHKOTTER, H ;

GOLD, JWM ;

ARMSTRONG, D .

JOURNAL OF INFECTIOUS DISEASES, 1988, 157 (05) :985-989

[7] CORTICOSTEROIDS AS ADJUNCTIVE THERAPY FOR SEVERE PNEUMOCYSTIS-CARINII PNEUMONIA IN THE ACQUIRED-IMMUNODEFICIENCY-SYNDROME - A DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL [J].

GAGNON, S ;

BOOTA, AM ;

FISCHL, MA ;

BAIER, H ;

KIRKSEY, OW ;

LAVOIE, L .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (21) :1444-1450

[8] INHALED OR INTRAVENOUS PENTAMIDINE THERAPY FOR PNEUMOCYSTIS-CARINII PNEUMONIA IN AIDS - A RANDOMIZED TRIAL [J].

HOO, GWS ;

MOHSENIFAR, Z ;

MEYER, RD .

ANNALS OF INTERNAL MEDICINE, 1990, 113 (03) :195-202

[9]

MCLEES BD, 1987, 3RD INT C AIDS WASH, P155

[10] ORAL-THERAPY FOR PNEUMOCYSTIS-CARINII PNEUMONIA IN THE ACQUIRED-IMMUNODEFICIENCY-SYNDROME - A CONTROLLED TRIAL OF TRIMETHOPRIM SULFAMETHOXAZOLE VERSUS TRIMETHOPRIM DAPSONE [J].

MEDINA, I ;

MILLS, J ;

LEOUNG, G ;

HOPEWELL, PC ;

LEE, B ;

MODIN, G ;

BENOWITZ, N ;

WOFSY, CB .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (12) :776-782