PROLIFERATIVE RESPONSE OF MAMMARY-GLAND MONONUCLEAR-CELLS TO RECOMBINANT BOVINE INTERLEUKIN-2

被引：9

作者：

TORRE, PM ^{[1
]}

KONUR, PK ^{[1
]}

OLIVER, SP ^{[1
]}

机构：

[1] UNIV TENNESSEE,INST AGR,DEPT ANIM SCI,KNOXVILLE,TN 37901

来源：

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 1992年 / 32卷 / 3-4期

关键词：

D O I：

10.1016/0165-2427(92)90056-V

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Methods of augmenting bovine mononuclear cell responsiveness during physiological transitions of the udder may enhance resistance of the mammary gland to intramammary infections. Interleukin-2 is required for proliferation of T-lymphocytes and may contribute to B-lymphocyte proliferation. Recombinant bovine interleukin-2 (rBoIL-2) was evaluated as a potential immunoenhancer of bovine mammary gland mononuclear cells. Bovine mononuclear cells were isolated from five primiparous Holstein cows at 14-18 and 28-32 days of involution and at 7-13 days prior to parturition. Bovine blood and mammary gland mononuclear cells were highly responsive to rBoIL-2. Response of mammary gland mononuclear cells to rBoIL-2 was comparable with response of blood mononuclear cells. These data suggest that rBoIL-2 may be an effective immunoenhancer of bovine mononuclear cells during the non-lactating and prepartum periods.

引用

页码：351 / 358

页数：8

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