STRUCTURE ACTIVITY-BASED PREDICTIVE TOXICOLOGY - AN EFFICIENT AND ECONOMICAL METHOD FOR GENERATING NONCONGENERIC DATA-BASES

被引：25

作者：

ROSENKRANZ, HS ^{[1
]}

TAKIHI, N ^{[1
]}

KLOPMAN, G ^{[1
]}

机构：

[1] CASE WESTERN RESERVE UNIV,DEPT CHEM,CLEVELAND,OH 44106

来源：

MUTAGENESIS | 1991年 / 6卷 / 05期

关键词：

D O I：

10.1093/mutage/6.5.391

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Starting with the results of the mutagenicity of 100 chemicals, we use CASE, a structure activity relational system, to select additional chemicals for inclusion into a data base. We demonstrate that a data base consisting of approximately 180 carefully selected chemicals is as predictive as the analysis based upon 820 'unselected' chemicals.

引用

页码：391 / 394

页数：4

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