THE HUMAN GENE FOR WATER CHANNEL AQUAPORIN-1 (AQP1) IS LOCALIZED ON CHROMOSOME-7P15-]P14

被引：18

作者：

DEEN, PMT

WEGHUIS, DO

VANKESSEL, AG

WIERINGA, B

VANOS, CH

机构：

[1] CATHOLIC UNIV NIJMEGEN, DEPT CELLULAR BIOL, 6500 HB NIJMEGEN, NETHERLANDS

[2] CATHOLIC UNIV NIJMEGEN, DEPT HUMAN GENET, 6500 HB NIJMEGEN, NETHERLANDS

来源：

CYTOGENETICS AND CELL GENETICS | 1994年 / 65卷 / 04期

关键词：

D O I：

10.1159/000133639

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The chromosomal localization of the gene encoding aquaporin 1 (previously called CHIP28), which acts as a water channel in erythrocytes and in the renal proximal tubules and descending limbs of Henle, was determined. Southern blot hybridizations on chromosomal DNA of a panel of 25 different human x rodent hybrid cell lines localized the aquaporin 1 gene to human chromosome 7. Additionally, in situ hybridization on R-banded metaphase chromosomes sublocalized the aquaporin 1 gene (AQP 1) to 7p15 --> p14, and some sequence-tagged sites in this region were identified.

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页码：243 / 246

页数：4

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