ATTEMPTED EXPERIMENTAL MODIFICATION OF THE POSTLAMINECTOMY MEMBRANE BY LOCAL INSTILLATION OF RECOMBINANT TISSUE-PLASMINOGEN ACTIVATOR GEL

被引：34

作者：

HENDERSON, R ^{[1
]}

WEIR, B ^{[1
]}

DAVIS, L ^{[1
]}

MIELKE, B ^{[1
]}

GRACE, M ^{[1
]}

机构：

[1] UNIV ALBERTA,FAC MED,DEPT SURG,2D102 MACKENZIE HLTH SCI CTR,8440-112 ST,EDMONTON T6G 2B7,AB,CANADA

来源：

SPINE | 1993年 / 18卷 / 10期

关键词：

POSTLAMINECTOMY MEMBRANE; EPIDURAL FIBROSIS; FAT GRAFT; TISSUE PLASMINOGEN ACTIVATOR;

D O I：

10.1097/00007632-199308000-00004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A prospective, randomized, blinded trail involving 25 adult mongrel dogs was performed to evaluate whether placement of a fat graft or local instillation of recombinant tissue-plasminogen activator gel (rt-PA) could modify the development of a postlaminectomy membrane. One component of the study involved the performance of a lumbar laminectomy and placement of gel re-PA, free fat, or no tissue placement over the exposed dura mater. Three months later the animals were killed and sections of spine were removed en bloc, decalcified, and examined histologically. No significant differences were found in the degree of cellular fibrosis or heavy collagen production. A similar laminectomy at another lumbar level was also followed by gel rt-PA, free fat, or no tissue placement. Three months after surgery, surgery was performed again at this level immediately before death. There were no differences in the adhesiveness of the laminectomy membrane to dura mater or roots. It was concluded that the local instillation of gel rt-PA after laminectomy did not inhibit scar formation or scar adherence to the dura matter.

引用

页码：1268 / 1272

页数：5

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