INFLAMMATION-INDUCED UP-REGULATION OF NK1 RECEPTOR MESSENGER-RNA IN DORSAL HORN NEURONS

被引：80

作者：

SCHAFER, MKH ^{[1
]}

NOHR, D ^{[1
]}

KRAUSE, JE ^{[1
]}

WEIHE, E ^{[1
]}

机构：

[1] WASHINGTON UNIV, SCH MED, DEPT ANAT & NEUROBIOL, ST LOUIS, MO 63110 USA

来源：

NEUROREPORT | 1993年 / 4卷 / 08期

关键词：

NK1; RECEPTOR; SPINAL CORD; INFLAMMATION; MESSENGER RNA; NUCLEIC ACID HYBRIDIZATION; TACHYKININ; NOCICEPTION; SUBSTANCE-P; PAIN; MOTONEURON;

D O I：

10.1097/00001756-199308000-00003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE expression of the neurokinin 1 (NK1) receptor (i.e. substance P receptor) gene in spinal cord was studied in rats subjected to unilateral inflammation by semi-quantitative in situ hybridization analysis. Low levels of NK1 receptor mRNA were detected in many neurones throughout the grey matter. Relatively strong labelling was observed in large motoneurones and a subpopulation of superficial dorsal horn neurones. Six days after Freund's adjuvant-induced unilateral hindpaw inflammation, NK1 receptor mRNA levels in lamina I/II of the dorsal horn ipsilateral to the inflamed paw increased almost two fold compared with the contralateral side. These data suggest an inflammation-induced increase of NK1 receptor synthesis in intrinsic spinal cord neurones involved in nociceptive neurotransmission.

引用

页码：1007 / 1010

页数：4

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