DOPAMINE AUTORECEPTOR AGONISTS - COMPUTATIONAL STUDIES, SYNTHESIS AND BIOLOGICAL INVESTIGATIONS

被引：17

作者：

GMEINER, P ^{[1
]}

SOMMER, J ^{[1
]}

MIERAU, J ^{[1
]}

HOFNER, G ^{[1
]}

机构：

[1] BOEHRINGER INGELHEIM KG,BIOCHEM FORSCH ABT,W-6507 INGELHEIM,GERMANY

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(00)80003-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Based on molecular modeling studies on the electronic properties of dopamine and dopamine agonists the pyrazolo[1,5-a]pyridine structure has been evaluated as a catechol surrogate. The azaergoline analogue 6, including this moiety has been synthesized via 1,3-dipolar cycloaddition, anionic ring closure and electrophilic amination. The target compounds (6) exhibit DA autoreceptor agonistic activity.

引用

页码：1477 / 1483

页数：7

共 28 条

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