LOSS OF FUNCTION OF THE DROSOPHILA-ZFH-1 GENE RESULTS IN ABNORMAL-DEVELOPMENT OF MESODERMALLY DERIVED TISSUES

被引：93

作者：

LAI, ZC

RUSHTON, E

BATE, M

RUBIN, GM

机构：

[1] UNIV CALIF BERKELEY,DEPT MOLEC & CELL BIOL,BERKELEY,CA 94720

[2] UNIV CAMBRIDGE,DEPT ZOOL,CAMBRIDGE CB2 3EJ,ENGLAND

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 09期

关键词：

ZINC FINGER; HOMEODOMAIN; MUSCLE DEVELOPMENT;

D O I：

10.1073/pnas.90.9.4122

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Drosophila zfh-1 gene encodes an unusual protein with nine Cys2His2 type zinc-ringer motifs and one homeodomain that shows a complex pattern of expression in the embryonic mesoderm and nervous system. To study the function of zfh-1, we generated loss-of-function zfh-1 mutations. Phenotypic analysis of zfh-1 mutant embryos reveals that the gene is not required for the initial segregation of the mesoderm or for the differentiation of mesodermally derived tissues. Rather, loss of zfh-1 function results in various degrees of local errors in cell fate or positioning.

引用

页码：4122 / 4126

页数：5

共 32 条

[1] DESPITE EXPRESSION IN EMBRYONIC VISCERAL MESODERM, H2.0 IS NOT ESSENTIAL FOR DROSOPHILA VISCERAL MUSCLE MORPHOGENESIS [J].