ANTIHISTONE ANTIBODIES IN PATIENTS WITH LOCALIZED SCLERODERMA

被引：104

作者：

SATO, S ^{[1
]}

IHN, H ^{[1
]}

SOMA, Y ^{[1
]}

IGARASHI, A ^{[1
]}

TAMAKI, T ^{[1
]}

KIKUCHI, K ^{[1
]}

ISHIBASHI, Y ^{[1
]}

TAKEHARA, K ^{[1
]}

机构：

[1] UNIV TOKYO, FAC MED, DEPT DERMATOL, 7-3-1 HONGO, BUNKYO KU, TOKYO 113, JAPAN

来源：

ARTHRITIS AND RHEUMATISM | 1993年 / 36卷 / 08期

关键词：

D O I：

10.1002/art.1780360815

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To study the prevalence and antigen specificity of antihistone antibodies (AHA) in localized scleroderma. Methods. Forty-nine serum samples from patients with localized scleroderma were examined by an enzyme-linked immunosorbent assay (ELISA) and by immunoblotting. Results. By ELISA, AHA were demonstrated in 47% (23 of 49) of patients with localized scleroderma and in 87% (13 of 15) of patients with generalized morphea. Immunoblotting revealed that the predominant antigens were histones H1 and H3. The presence of AHA correlated with that of anti-single-stranded DNA antibody. Conclusion. Some of the major antigens for antinuclear antibodies in patients with localized scleroderma are histones.

引用

页码：1137 / 1141

页数：5

共 15 条

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