OCCURRENCE OF THE NITROSAMIDE PRECURSOR PYRROLIDIN-(2)-ONE IN FOOD AND TOBACCO

被引：7

作者：

MENDE, P ^{[1
]}

ZIEBARTH, D ^{[1
]}

PREUSSMANN, R ^{[1
]}

SPIEGELHALDER, B ^{[1
]}

机构：

[1] MAX DELBRUCK CTR,BERLIN,GERMANY

来源：

CARCINOGENESIS | 1994年 / 15卷 / 04期

关键词：

D O I：

10.1093/carcin/15.4.733

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pyrrolidinone was identified in food and tobacco samples by gas chromatography combined with NO-specific chemiluminescence detection (TEA). Up to 77 mg/kg pyrrolidinone were detected in cocoa powders, coffee, coffee surrogates, dried vegetables and tobacco leaves. When treated with excess nitrite under acidic conditions, N-nitrosopyrrolidinone was formed in concentrations up to 44 mg/kg. The nitrosation characteristics of pyrrolidinone indicate its possible conversion to nitrosopyrrolidinone under conditions of the gastric tract.

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页码：733 / 737

页数：5

相关论文

共 21 条

[1] TRIMETHYLSILYLATION OF AMINO ACIDS .2. GAS CHROMATOGRAPHIC AND STRUCTURAL STUDIES ON TRIMETHYLSILYL DERIVATIVES OF STRAIGHT CHAIN AMINO ACIDS [J].

BERGSTROM, K ;

GURTLER, J .

ACTA CHEMICA SCANDINAVICA, 1971, 25 (01) :175-+

[2] CHEMISTRY OF NITROSO-COMPOUNDS .9. GENERAL ACID-CATALYZED DECOMPOSITION OF N-NITROSO-2-PYRROLIDONE, AN EXAMPLE OF AMIDE HYDROLYSIS VIA SN2 DISPLACEMENT ON N-CONJUGATE ACID [J].

CHALLIS, BC ;

JONES, SP .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1975, (02) :153-160

[3] INVESTIGATIONS ON THE ORIGIN OF TOBACCO-SPECIFIC NITROSAMINES IN MAINSTREAM SMOKE OF CIGARETTES [J].

FISCHER, S ;

SPIEGELHALDER, B ;

EISENBARTH, J ;

PREUSSMANN, R .

CARCINOGENESIS, 1990, 11 (05) :723-730

[4] AN INVESTIGATION INTO THE POTENTIAL FORMATION OF N-SUBSTITUTED AMIDES AND THEIR NITROSATED DERIVATIVES DURING THE FRYING OF BACON [J].

FOOLADI, MH ;

GRAY, JI ;

PEARSON, AM ;

MANDAGERE, AK .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1983, 31 (03) :527-530

[5]

GABRIEL S, 1889, CHEM BER, V22, P3335

[6] CHANGES IN FREE AMINO ACIDS OF TOMATO FRUIT UNDER PATHOGENESIS [J].

KAPOOR, IJ ;

TANDON, RN .

NATURWISSENSCHAFTEN, 1969, 56 (01) :40-&

[7]

KAWABATA T, 1979, B JPN SOC SCI FISH, V45, P971

[8] VOLATILE COMPOSITION OF WHITE BREAD USING ENZYME ACTIVE SOYA FLOUR AS IMPROVER [J].

LUNING, PA ;

ROOZEN, JP ;

MOEST, RAFJ ;

POSTHUMUS, MA .

FOOD CHEMISTRY, 1991, 41 (01) :81-91

[9]

MENDE P, 1991, FOOD CHEM TOXICOL, V27, P475

[10] PERCUTANEOUS-ABSORPTION OF CO-ADMINISTERED N-METHYL-2-[C-14]PYRROLIDINONE AND 2-[C-14]PYRROLIDINONE IN THE RAT [J].

MIDGLEY, I ;

HOOD, AJ ;

CHASSEAUD, LF ;

BRINDLEY, CJ ;

BAUGHMAN, S ;

ALLAN, G .

FOOD AND CHEMICAL TOXICOLOGY, 1992, 30 (01) :57-64