SYNTHESIS OF (R)-(+)-BOC-ITURINIC ACID (N-C-14) FROM ASPARTIC-ACID

被引：9

作者：

BLAND, JM

机构：

[1] USDA, Agricultural Research Service, Southern Regional Research Center, New Orleans, LA 70124

来源：

SYNTHETIC COMMUNICATIONS | 1995年 / 25卷 / 04期

关键词：

D O I：

10.1080/00397919508011380

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first enantiospecific synthesis of the n-C14 isomer of iturinic acid, suitably protected for peptide synthesis, is presented. A new method for the synthesis of enantiomerically pure beta-amino acids from aspartic acid is used. The key step consists of an organocuprate addition to a tosylate derivative of aspartic acid, reduced at the alpha-carboxylic acid.

引用

页码：467 / 477

页数：11

共 14 条

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[2]

BREWSTER JH, 1992, CHEM ENG NEWS, V70, P3

[3] ASYMMETRIC-SYNTHESIS OF R-BETA-AMINO BUTANOIC ACID AND S-BETA-TYROSINE - HOMOCHIRAL LITHIUM AMIDE EQUIVALENTS FOR MICHAEL ADDITIONS TO ALPHA,BETA-UNSATURATED ESTERS [J].