STUDIES IN PREBIOTIC SYNTHESIS .4. CONVERSION OF 4-AMINOIMIDAZOLE-5-CARBONITRILE DERIVATIVES TO PURINES

被引：90

作者：

SANCHEZ, RA

FERRIS, JP

ORGEL, LE

机构：

[1] The Salk Institute for Biological Studies San Diego

来源：

JOURNAL OF MOLECULAR BIOLOGY | 1968年 / 38卷 / 01期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/0022-2836(68)90132-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of 4-aminoimidazole-5-carbonitrile and its derivatives from HCN has been discussed in a preceding paper. It is shown here that these imidazoles are readily cyclized to mono- and di-substituted purines. Since the photochemical synthesis of 4-aminoimidazole-5-carbonitrile from HCN is considered to be a particularly plausible prebiotic pathway, the conversion of 4-aminoimidazole-5-carbonitrile and of its hydrolysis product 4-aminoimidazole-5-carboxamide to adenine and guanine are examined in some detail. © 1968.

引用

页码：121 / +

页数：1

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