XANTHINE-7-RIBOSIDES AS ADENOSINE-A1 RECEPTOR ANTAGONISTS - FURTHER EVIDENCE FOR ADENOSINES ANTI MODE OF BINDING

被引：25

作者：

VANGALEN, PJM

IJZERMAN, AP

SOUDIJN, W

机构：

[1] Div. of Medicinal Chemistry, Center for Bio-Pharmaceutical Sciences, 2300, RA, Leiden

来源：

NUCLEOSIDES & NUCLEOTIDES | 1990年 / 9卷 / 02期

关键词：

D O I：

10.1080/07328319008045138

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis and A1 adenosine receptor affinity of some xanthine-7-ribosides is described. It appears that these compounds are Ai receptor antagonists. The orientation of the ribose moiety, as determined by 1H-NMR spectroscopy and theoretical chemical calculations, is compared with the orientation of the ribose in the agonist adenosine. Implications for the syn vs anti modes of binding to the receptor are discussed. © 1990, Taylor & Francis Group, LLC. All rights reserved.

引用

页码：275 / 291

页数：17

共 29 条

[1] MOLECULAR ORBITAL CALCULATIONS ON CONFORMATION OF NUCLEIC ACIDS AND THEIR CONSTITUENTS .1. CONFORMATIONAL ENERGIES OF BETA-NUCLEOSIDES WITH C(3')- AND C(2')-ENDO SUGARS [J].