SERUM ANTIBODIES TO PEPTIDOGLYCAN-POLYSACCHARIDE COMPLEXES FROM THE ANAEROBIC INTESTINAL FLORA IN PATIENTS WITH CROHNS-DISEASE

被引：17

作者：

HAZENBERG, MP

DEVISSER, H

BRAS, MJJ

PRINS, ME

VANDEMERWE, JP

机构：

[1] Department of Immunology, Erasmus University, Rotterdam

来源：

DIGESTION | 1990年 / 47卷 / 03期

关键词：

CROHNS DISEASE; BACTERIA; ANAEROBIC; PEPTIDOGLYCAN;

D O I：

10.1159/000200494

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Soluble peptidoglycan-polysaccharide complexes (PPC) isolated from feces of a healthy subject shared antigens with 22 out of 40 anaerobic intestinal bacteria and, therefore, these could be considered as flora derived. IgG, IgA and IgM antibodies against PPC were found in sera from healthy subjects, patients with Crohn's disease (CD) and other patients. In sera of CD patients with agglutinating antibodies to 4 anaerobic intestinal bacteria (used as an acid for diagnosis of CD) IgG and Iga levels to PPC were higher than in CD patients without these antibodies.

引用

收藏

页码：172 / 180

页数：9

相关论文

共 26 条

[1] COMPARISON OF FECAL MICROFLORA OF ELDERLY PERSONS IN RURAL AND URBAN AREAS OF JAPAN [J].

BENNO, Y ;

ENDO, K ;

MIZUTANI, T ;

NAMBA, Y ;

KOMORI, T ;

MITSUOKA, T .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1989, 55 (05) :1100-1105

[2] ANTIBODY-RESPONSE TO ANAEROBIC COCCOID RODS IN CROHNS-DISEASE [J].

BULL, K ;

MATTHEWS, N ;

RHODES, J .

JOURNAL OF CLINICAL PATHOLOGY, 1986, 39 (10) :1130-1134

[3] INVESTIGATION OF MYCOBACTERIA IN CROHNS-DISEASE TISSUE BY SOUTHERN BLOTTING AND DNA HYBRIDIZATION WITH CLONED MYCOBACTERIAL GENOMIC DNA PROBES FROM A CROHNS-DISEASE ISOLATED MYCOBACTERIA [J].

BUTCHER, PD ;

MCFADDEN, JJ ;

HERMONTAYLOR, J .

GUT, 1988, 29 (09) :1222-1228

[4]

Chen J. -S., 1977, ANAEROBE LAB MANUAL, VFourth

[5] POSSIBLE ROLE OF MYCOBACTERIA IN INFLAMMATORY BOWEL-DISEASE .1. AN UNCLASSIFIED MYCOBACTERIUM SPECIES ISOLATED FROM PATIENTS WITH CROHNS-DISEASE [J].

CHIODINI, RJ ;

VANKRUININGEN, HJ ;

THAYER, WR ;

MERKAL, RS ;

COUTU, JA .

DIGESTIVE DISEASES AND SCIENCES, 1984, 29 (12) :1073-1079

[6] PRELIMINARY-REPORT ON ISOLATION OF MYCOBACTERIA FROM PATIENTS WITH CROHNS-DISEASE [J].

GITNICK, G ;

COLLINS, J ;

BEAMAN, B ;

BROOKS, D ;

ARTHUR, M ;

IMAEDA, T ;

PALIESCHESKY, M .

DIGESTIVE DISEASES AND SCIENCES, 1989, 34 (06) :925-932

[7]

HAZENBERG MP, 1989, EUR J CLIN INVEST, V19, P61, DOI 10.1111/j.1365-2362.1989.tb00196.x

[8]

HELPHINGSTINE CJ, 1979, J CLIN MICROBIOL, V9, P373

[9] NEW AND IMPROVED MICROASSAY TO DETERMINE 2-KETO-3-DEOXYOCTONATE IN LIPOPOLYSACCHARIDE OF GRAM-NEGATIVE BACTERIA [J].

KARKHANIS, YD ;

ZELTNER, JY ;

JACKSON, JJ ;

CARLO, DJ .

ANALYTICAL BIOCHEMISTRY, 1978, 85 (02) :595-601

[10] IMMUNOHISTOCHEMICAL EXAMINATION FOR MYCOBACTERIA IN INTESTINAL TISSUES FROM PATIENTS WITH CROHNS-DISEASE [J].

KOBAYASHI, K ;

BLASER, MJ ;

BROWN, WR .

GASTROENTEROLOGY, 1989, 96 (04) :1009-1015