THE DISPOSITION OF IVERMECTIN IN ATLANTIC SALMON (SALMO-SALAR)

被引：54

作者：

HOY, T ^{[1
]}

HORSBERG, TE ^{[1
]}

NAFSTAD, I ^{[1
]}

机构：

[1] NORWEGIAN COLL VET MED,DEPT PHARMACOL & TOXICOL,POB 8146 DEP,N-0033 OSLO 1,NORWAY

来源：

PHARMACOLOGY & TOXICOLOGY | 1990年 / 67卷 / 04期

关键词：

D O I：

10.1111/j.1600-0773.1990.tb00835.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The disposition of tritium‐labelled ivermectin (22, 23 di‐3H‐avermectin, B1a) in Atlantic salmon was studied by whole‐body autoradiography, liquid scintillation counting, and thin‐layer chromatography. Ivermectin was slowly absorbed, the highest concentrations being found in lipid‐containing organs. High concentrations were also found in the central nervous system, indicating that the blood‐brain barrier in salmon is poorly developed compared to mammals. The excretion of the drug was very slow. The total amount of radioactivity in blood, muscle, liver and kidney diminished by only 35% from day 4 to day 28 after administration. Excretion was mainly by the biliary route, and enterohepatic circulation of the drug was apparent. The drug was mainly excreted in the unchanged form. Distribution to the central nervous system, and the prolonged excretion period, makes the drug unsuitable for the control of parasitic infestations in salmon. 1990 Nordic Pharmacological Society

引用

页码：307 / 312

页数：6

共 13 条

[1] AVERMECTINS, NEW FAMILY OF POTENT ANTHELMINTIC AGENTS - PRODUCING ORGANISM AND FERMENTATION [J].

BURG, RW ;

MILLER, BM ;

BAKER, EE ;

BIRNBAUM, J ;

CURRIE, SA ;

HARTMAN, R ;

KONG, YL ;

MONAGHAN, RL ;

OLSON, G ;

PUTTER, I ;

TUNAC, JB ;

WALLICK, H ;

STAPLEY, EO ;

OIWA, R ;

OMURA, S .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1979, 15 (03) :361-367

[2] IVERMECTIN - A POTENT NEW ANTI-PARASITIC AGENT [J].

CAMPBELL, WC ;

FISHER, MH ;

STAPLEY, EO ;

ALBERSSCHONBERG, G ;

JACOB, TA .

SCIENCE, 1983, 221 (4613) :823-828

[3] QUANTITATIVE METHOD FOR MEASURING RADIOACTIVITY IN TISSUES SECTIONED FOR WHOLE-BODY AUTORADIOGRAPHY [J].

CROSS, SAM ;

GROVES, AD ;

HESSELBO, T .

INTERNATIONAL JOURNAL OF APPLIED RADIATION AND ISOTOPES, 1974, 25 (09) :381-386

[4]

ELLIS AE, 1985, GRUNDLAGEN FISCHPATH, P23

[5] AVERMECTIN-B1A IRREVERSIBLY BLOCKS POSTSYNAPTIC POTENTIALS AT THE LOBSTER NEUROMUSCULAR-JUNCTION BY REDUCING MUSCLE MEMBRANE RESISTANCE [J].

FRITZ, LC ;

WANG, CC ;

GORIO, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (04) :2062-2066

[6]

JACOB TA, 1983, RECENT DEV CONTROL A, P56

[7]

LEECHIU SH, 1986, DRUG METAB DISPOS, V14, P590

[8] POSTSYNAPTIC INHIBITION OF INVERTEBRATE NEUROMUSCULAR-TRANSMISSION BY AVERMECTIN-B1A [J].

MELLIN, TN ;

BUSCH, RD ;

WANG, CC .

NEUROPHARMACOLOGY, 1983, 22 (01) :89-96

[9]

NESSEL RJ, 1983, RECENT DEV CONTROL A, P98

[10]

Palmer R., 1987, Bulletin of the European Association of Fish Pathologists, V7, P47

← 1 2 →