SYNTHESIS OF 1-(2,3-DIDEOXY-2-FLUORO-BETA-D-THREO-PENTOFURANOSYL)CYTOSINE (F-DDC) - A PROMISING AGENT FOR THE TREATMENT OF ACQUIRED-IMMUNE-DEFICIENCY-SYNDROME

被引：78

作者：

OKABE, M

SUN, RC

ZENCHOFF, GB

机构：

[1] Roche Research Center, Hoffmann-La Roche Inc., Nutley

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1991年 / 56卷 / 14期

关键词：

D O I：

10.1021/jo00014a013

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new and practical synthesis of a fluorinated analogue of 2',3'-dideoxycytidine (ddC), 1-(2,3-dideoxy-2-fluoro-beta-D-threo-pentofuranosyl)cytosine (F-ddC), is described. The key feature in the synthesis is the use of the selectively protected 2,4,5-trihydroxypentanoic acid derivative 15 as a chiral pool synthon.

引用

页码：4392 / 4397

页数：6

共 26 条

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