VERY-LATE-ONSET ADRENOLEUKODYSTROPHY - POSSIBLE PRECIPITATION OF DEMYELINATION BY CEREBRAL CONTUSION

被引：29

作者：

WELLER, M

LIEDTKE, W

PETERSEN, D

OPITZ, H

POREMBA, M

机构：

[1] UNIV TUBINGEN,DEPT NEUROL,HOPPE SEYLER STR 3,W-7400 TUBINGEN 1,GERMANY

[2] UNIV TUBINGEN,DEPT NEURORADIOL,W-7400 TUBINGEN 1,GERMANY

[3] UNIV TUBINGEN,INST BRAIN RES,W-7400 TUBINGEN 1,GERMANY

来源：

NEUROLOGY | 1992年 / 42卷 / 02期

关键词：

D O I：

10.1212/WNL.42.2.367

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report the clinical history, neuroradiology, and autopsy findings in a patient with very late onset, at age 57, of adrenoleukodystrophy (ALD) presenting with dementia, hemianopia, and gait apraxia. Open brain biopsy, elevated plasma very-long-chain fatty acids, and autopsy confirmed the diagnosis of ALD. Demyelinative lesions were most extensive at the site of a recent cerebral contusion. CNS trauma may have precipitated or accelerated demyelination in this patient carrying the ALD gene.

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页码：367 / 370

页数：4

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