INFLUENCE OF DIETARY IRON OVERLOAD ON CELL-PROLIFERATION AND INTESTINAL TUMORIGENESIS IN MICE

被引：54

作者：

SIEGERS, CP ^{[1
]}

BUMANN, D ^{[1
]}

TREPKAU, HD ^{[1
]}

SCHADWINKEL, B ^{[1
]}

BARETTON, G ^{[1
]}

机构：

[1] MED UNIV LUBECK,INST PATHOL,W-2400 LUBECK,GERMANY

来源：

CANCER LETTERS | 1992年 / 65卷 / 03期

关键词：

DIMETHYLHYDRAZINE; COLON TUMORIGENESIS; IRON CONCENTRATION; MALONALDEHYDE; CELL PROLIFERATION; OXIDATIVE STRESS;

D O I：

10.1016/0304-3835(92)90239-R

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Iron-enriched diets caused an increase of tumor rate in two models of dimethylhydrazine(DMH)-induced colon tumorigenesis in mice. The effect was independent of the time the iron-diet was fed, i.e. during DMH-treatment or following the DMH-treatment period. The increase of tumor rate depended on the iron concentration in the diet (0.5-3.5%). The concentration-dependent iron accumulation in the colonic mucosa of mice was paralleled by increments of malonaldehyde contents indicating lipid peroxidation, another factor known to be involved in tumor development. It is suggested that iron exerts cocarcinogenic activity in the DMH-model by stimulating cell proliferation and inducing oxidative stress in the colonic mucosa. This effect of iron is independent of the time of tumor-initiation by DMH, as it is also observed in the period of tumor-promotion/progression after DMH-treatment.

引用

页码：245 / 249

页数：5

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