EVIDENCE THAT MATRIX RECOGNITION CONTRIBUTES TO STABILIZATION BUT NOT INDUCTION OF LTP

被引：64

作者：

PENG, X ^{[1
]}

BAHR, BA ^{[1
]}

STAUBLI, U ^{[1
]}

VANDERKLISH, PW ^{[1
]}

LYNCH, G ^{[1
]}

机构：

[1] UNIV CALIF IRVINE, CTR NEUROBIOL LEARNING & MEMORY, IRVINE, CA 92717 USA

来源：

NEUROREPORT | 1991年 / 2卷 / 08期

关键词：

SYNAPTIC ADHESION; INTEGRIN; LTP; RGD; ARG GLY ASP; RAT BRAIN; HIPPOCAMPUS;

D O I：

10.1097/00001756-199108000-00013

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

SLICES of hippocampus were incubated with Arg-Gly-Asp (RGD) peptides known to block members of the integrin class of matrix receptors. Though the peptides caused no detectable difference in the amount of long-term potentiation (LTP) expressed in the CA1 field 1-2 min after induction with high frequency stimulation, they did produce a reversible, dose dependent decay of LTP over a period of 40 min. This effect was not obtained with various non-RGD control peptides. These results suggest that stabilization of LTP requires adhesive interactions via specific matrix recognition sites, whereas induction and expression do not.

引用

页码：461 / 464

页数：4

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