EFFECTS OF LESIONS OF LOCUS-CERULEUS SUBCOERULEUS ON DIFFUSE NOXIOUS INHIBITORY CONTROLS IN THE RAT

被引：37

作者：

BOUHASSIRA, D ^{[1
]}

ZHU, B ^{[1
]}

LEBARS, D ^{[1
]}

机构：

[1] INSERM, U161, 2 RUE ALESIA, F-75014 PARIS, FRANCE

来源：

BRAIN RESEARCH | 1992年 / 571卷 / 01期

关键词：

PAIN; TRIGEMINAL NUCLEUS; PAIN MODULATION; LOCUS CERULEUS;

D O I：

10.1016/0006-8993(92)90520-J

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Diffuse noxious inhibitory controls (DNIC) acting on trigeminal convergent neurons were compared in sham-operated animals and rats with quinolinic acid induced lesions of the locus coeruleus/subcoeruleus (LC/SC). No significant differences were observed between control animals and those with ipsilateral, contralateral or bilateral lesions of the LC/SC, in respect of: (1) the general properties of the recorded units; and (2) the magnitude of the depressions of C-fiber-evoked responses of convergent neurons produced by immersing each paw in a 50-degrees-C water bath (i.e. DNIC). It is concluded that the LC/SC is not involved, at least directly, in the supraspinal part of the loop which subserves DNIC in the rat.

引用

页码：140 / 144

页数：5

共 29 条

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