THE STEPWISE SYNTHESIS OF OLIGO(GLYCOSYL PHOSPHATES) VIA GLYCOSYL HYDROGENPHOSPHONATES - THE CHEMICAL SYNTHESIS OF OLIGOMERIC FRAGMENTS FROM HANSENULA-CAPSULATA Y-1842 EXOPHOSPHOMANNAN AND FROM ESCHERICHIA-COLI K51 CAPSULAR ANTIGEN

被引：30

作者：

NIKOLAEV, AV ^{[1
]}

IVANOVA, IA ^{[1
]}

SHIBAEV, VN ^{[1
]}

机构：

[1] ND ZELINSKII INST ORGAN CHEM,MOSCOW,RUSSIA

来源：

CARBOHYDRATE RESEARCH | 1993年 / 242卷

关键词：

D O I：

10.1016/0008-6215(93)80024-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A stepwise approach has been used in the syntheses of pentamannosyl tetraphosphate HO-[-6Man(alpha)-PO4-]4-6Man(alpha)-OMe and tetra(N-acetylglucosaminyl) triphosphate HO-[-3GlcNAc(alpha)-PO4]3-3GlcNAc(beta)-OC6H4NO2, which are fragments of the yeast and bacteria extracellular phospho-glycans. Elongation of the chain was performed with the use of suitably protected glycosyl hydrogen-phosphonate derivatives for successive introduction of glycosyl phosphate residues. Partially protected monosaccharide derivatives and oligomeric blocks served as hydroxylic components.

引用

页码：91 / 107

页数：17

共 15 条

[1] SELECTIVE REMOVAL OF O-ACETYL GROUPS IN THE PRESENCE OF O-BENZOYL GROUPS BY ACID-CATALYZED METHANOLYSIS [J].