FETAL ENTEROVIRAL INFECTION WITH CEREBRAL VENTRICULOMEGALY AND CARDIOMYOPATHY

被引:14
作者
DOMMERGUES, M
PETITJEAN, J
AUBRY, MC
DELEZOIDE, AL
NARCY, F
FALLETBIANCO, C
FREYMUTH, F
DUMEZ, Y
LEBON, P
机构
[1] Laboratoire de virologie, CHU, Caen
[2] Maternité Port, Royal-Baudelocque
[3] Laboratoire d’anatomie pathologique, Hôpital Cochin
[4] Service d’Histo-Embryologie, Hôpital Necker-Enfants Malades
[5] Laboratoire de virologie, Hôpital Saint Vincent de Paul, Paris
关键词
CEREBRAL VENTRICULOMEGALY; CARDIOMYOPATHY; ENTEROVIRUS; INTERFERON; PRENATAL DIAGNOSIS;
D O I
10.1159/000263911
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Fetal cerebral ventriculomegaly and cardiomyopathy were diagnosed prenatally at 35 weeks and resulted in fetal death. Although there was no post mortem pathological evidence of inflammatory lesions, fetal serum alpha interferon was abnormally high (25 IU/ml). Virologic investigations were therefore carried out on stored amniotic fluid, fetal and maternal blood samples. The presence of enterovirus was retrospectively demonstrated in amniotic fluid. The association of fetal birth defects with enteroviral infection is puzzling and suggests that more attention should be given to virologic studies in the diagnostic workup of fetal malformations otherwise considered as idiopathic.
引用
收藏
页码:77 / 78
页数:2
相关论文
共 5 条
[1]  
Gresser I., Bandu M.T., Brouty-Boye D., Tovey M., Pronounced antiviral activity of human interferon on bovine and porcine cells, Nature, 251, pp. 541-543, (1974)
[2]  
Lebon P., Daffos F., Checoury A., Forrestier F., Toutblanc J., Presence of an acid-labile alpha interferon in sera from fetuses and children with congenital rubella, J Clin Microbiol, 21, pp. 775-778, (1985)
[3]  
Pelitjean J., Quibriac M., Freyinulh F., Specific detection of enteroviruses in clinical samples by molecular hybridization using poliovirus subgenomic riboprobes, J Clin Microbiol, 28, pp. 307-311, (1990)
[4]  
Gauntt C.J., Gudvangcn R.J., Brans Y.W., Marlin A., Coxsackieviruses group B antibodies in the ventricular fluid of infants with severe anatomic defects in the central nervous system, Pediatrics, 76, pp. 64-68, (1985)
[5]  
McKover H., Skurska Z., Halazinska L., A transplacental infection with Coxsackie A4 virus, Tex Rep Biol Med, 16, pp. 346-349, (1958)