IN-VITRO ANTIFUNGAL ACTIVITY OF TRITERPENOID SAPONINS

被引：70

作者：

FAVEL, A ^{[1
]}

STEINMETZ, MD ^{[1
]}

REGLI, P ^{[1
]}

VIDALOLLIVIER, E ^{[1
]}

ELIAS, R ^{[1
]}

BALANSARD, G ^{[1
]}

机构：

[1] FAC PHARM MARSEILLE,PHARMACOGNOSIE LAB,F-13385 MARSEILLE 5,FRANCE

来源：

PLANTA MEDICA | 1994年 / 60卷 / 01期

关键词：

TRITERPENOID SAPONINS; ANTIFUNGAL ACTIVITY; HEDERAGENIN; MONODESMOSIDES; CANDIDA GLABRATA; DERMATOPHYTES;

D O I：

10.1055/s-2006-959407

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The antifungal activity of triterpenoid saponins, with hederagenin or oleanolic acid as aglycone, was investigated in vitro by the agar dilution method. Monodesmosidic hederagenin derivatives were shown to exhibit a broad spectrum of activity against yeast as well as dermatophyte species. alpha-Hederin was the most active compound, and Candida glabrata was the most susceptible strain. The structure-activity relationships are discussed.

引用

页码：50 / 53

页数：4

共 20 条

[1]

BADER G, 1990, PHARMAZIE, V45, P618

[2]

DEBONO M, 1990, HDB EXPT PHARM, V96, P77

[3] TRITERPENOID SAPONINS FROM THE LEAVES OF HEDERA-HELIX [J].

ELIAS, R ;

LANZA, AMD ;

VIDALOLLIVIER, E ;

BALANSARD, G ;

FAURE, R ;

BABADJAMIAN, A .

JOURNAL OF NATURAL PRODUCTS, 1991, 54 (01) :98-103

[4]

Fromtling R. A., 1987, Recent trends in the discovery, development and evaluation of antifungal agents., P7

[5] BIOACTIVITY IN PLANTS - THE LINK BETWEEN PHYTOCHEMISTRY AND MEDICINE [J].

HAMBURGER, M ;

HOSTETTMANN, K .

PHYTOCHEMISTRY, 1991, 30 (12) :3864-3874

[6] THE STRUCTURE-HEMOLYSIS RELATIONSHIP OF OLEANOLIC ACID-DERIVATIVES AND INHIBITION OF THE SAPONIN-INDUCED HEMOLYSIS WITH SAPOGENINS [J].

HASE, J ;

KOBASHI, K ;

MITSUI, K ;

NAMBA, T ;

YOSHIZAKI, M ;

TOMIMORI, T .

JOURNAL OF PHARMACOBIO-DYNAMICS, 1981, 4 (11) :833-837

[7]

HILLER K, 1975, PHARMAZIE, V30, P114

[8]

KAWAI H, 1988, CHEM PHARM BULL, V36, P4769

[9]

KIMATA H, 1983, CHEM PHARM BULL, V31, P1998

[10] TRITERPENOID SAPONINS [J].

MAHATO, SB ;

SARKAR, SK ;

PODDAR, G .

PHYTOCHEMISTRY, 1988, 27 (10) :3037-3067

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